WP3 aims at:
Identifying non-invasive surrogate markers of vascular complications for use in diabetic patients, suitable to monitor atherosclerosis and retinopathy with sensitivity and diagnostic accuracy even with relatively small sample sizes and short follow-up periods.
New imaging techniques
Developing a technical platform allowing a non-invasive characterization of carotid plaque structure in the form of a virtual histology. The technique is validated against carotid ultrasound, plaque echogenicity, endothelial dysfunction and arterial stiffness in a multi-centre study involving 500 diabetic patients with cardiovascular disease, 500 diabetic patients without cardiovascular disease and 500 non-diabetic control patients.
Examing in a multi-centre study involving 2000 patients whether local retinal thickness in diabetes, as assessed by Optical Coherence Tomography (OCT), changes before or in parallel with morphological changes in type 2 diabetes.
Work Package 3 (WP3)